Publications/Patents/Spin-offs

• Escudeiro-Lopes, S.; Gonzalez-Morena, J. M.; Baudysova, A.; Svoboda, M.; Marasek, P.; Rodriguez-Gomez, G.; Ferreira Mendes, J.; Phang, C. W.; Miryala, S. K.; Jakoube, P.; Kovarova, B.; Machado, S.; Feng, Y.; Keckesova, Z. The role of autoproteolysis and mitoribosomal proteins in regulation of mitochondrial LACTB tumor suppressor. bioRxiv 2025.12.13.694101. https://doi.org/10.64898/2025.12.13.694101
• Chan, E. M.; Chhabra, Y.; Dixon, K. O.; Durbin, A. D.; Färkkilä, A.; Jeyasekharan, A. D.; Keckesova, Z.; Prensner, J. R.; Wagenblast, E.; Xie, S. Z.; Zhao, D. Insights on Future Directions in Cancer Research from the 2025 AACR NextGen Stars. Cancer Discov. 2025, 15, 678–684. https://doi.org/10.1158/2159-8290.CD-25-0239
• Cutano, V.; Ferreira Mendes, J.M.; Escudeiro-Lopes, S.; Machado, S.; Vinaixa Forner, J.; Gonzales-Morena, J.M.; Prevorovsky, M.; Zemlianski, V.; Feng, Y.; Kralova Viziova, P.; Hartmanova, A.; Malcekova, B.; Jakoube, P.; Iyer, S.; Keckesova, Z. LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug. Life Sci. Alliance 2023, 6, e202201510. DOI: 10.26508/lsa.202201510
• Gonzalez-Morena, J. M.; Escudeiro-Lopes, S.; Ferreira-Mendes, J. M.; Jakoube, P.; Cutano, V.; Vinaixa-Forner, J.; Kralova Viziova, P.; Hartmanova, A.; Sedlacek, R.; Machado, S.; Malcekova, B.; Keckesova, Z. LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer. Apoptosis 2022. DOI: 10.1007/s10495-022-01775-4
• Zhao, J.-S.; Shi, S.; Qu, H.-Y.; Keckesova, Z.; Cao, Z.-J.; Yang, L.-X.; Yu, X.; Feng, L.; Shi, Z.; Krakowiak, J.; Mao, R.-Y.; Shen, Y.-T.; Fan, Y.-M.; Fu, T.-M.; Ye, C.; Xu, D.; Gao, X.; You, J.; Li, W.; Liang, T.; Lu, Z.; Feng, Y.-X. Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth. Nat. Metab. 2022, 4, 239–253. DOI: 10.1038/s42255-021-00524-2
• Jakoube, P.; Cutano, V.; González-Morena, J. M.; Keckesova, Z. Mitochondrial Tumor Suppressors—The Energetic Enemies of Tumor Progression. Cancer Res. 2021, 81, 4652–4667. DOI: 10.1158/0008-5472.CAN-21-0518
  

Three international patents filed in 2024 for oncology-based therapeutics

Our group was established in 2018. These are some of our previous papers we are building on in our research:

• Kečkéšová, Z.; Donaher, J.L.; De Cock, J.; Freinkman, E.; Lingrell, S.; Bachovchin, D.A.; Bierie, B.; Tischler, V.; Noske, A.; Reinhardt, F.; Thiru, P.; Golub, T.R.; Vance, J.E.; Weinberg, R.A. LACTB is a tumor suppressor that modulates lipid metabolism and cell state. Nature 2017, 543, 681–686. DOI: 10.1038/nature21408
• Dongre, A.; Rashidian, M.; Reinhardt, F.; Bagnato, A.; Kečkéšová, Z.; Ploegh, H.L.; Weinberg, R.A. The epithelial-to-mesenchymal transition contributes to immune suppression in breast carcinomas. Cancer Res. 2017, 77, 3982–3989. DOI: 10.1158/0008-5472.CAN-16-3292
• Bierie, B.; Pierce, S.E.; Kroeger, C.; Stover, D.G.; Pattabiraman, D.R.; Thiru, P.; Liu Donaher, J.; Reinhardt, F.; Chaffer, C.L.; Kečkéšová, Z.; Weinberg, R.A. Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. PNAS 2017, 114, E2337–2346. DOI: 10.1073/pnas.1618298114
• De Cock, J.M.; Shibue, T.; Dongre, A.; Kečkéšová, Z.; Reinhardt, F.; Weinberg, R.A. Inflammation triggers Zeb1-dependent escape from latency. Cancer Res. 2016, 76, 6778–6784. DOI: 10.1158/0008-5472.CAN-16-0608
• Guo, W.; Kečkéšová, Z.; Donaher, J.L.; Reinhardt, F.; Shibue, T.; Itzkovitz, S.; Bell, G.; von Oudenaarden, A.; Weinberg, R.A. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell 2012, 148, 1015–1028. DOI: 10.1016/j.cell.2012.02.008
• Kečkéšová, Z.; Roussos, E.T.; Haley, J.D.; Epstein, D.M.; Weinberg, R.A.; Condeelis, J.S. AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res. 2010, 70, 7360–7364. DOI: 10.1158/0008-5472.CAN-10-1208